解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The members of the tumour necrosis factor (TNF) superfamily of cytokines play important roles in the regulation of various immune-cell functions. Likewise, induction of cell death by apoptosis is indispensable for the normal functioning of the immune system. There are two major pathways of apoptosis induction. The int...
journal_title:Immunology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2567.2009.03058.x
更新日期:2009-06-01 00:00:00
abstract::Human neutrophils express Toll-like receptor 4 (TLR4) at low levels, and the role of this receptor in neutrophil responses to microbial stimuli has been questioned. Genetic manipulation of these cells to enable the study of the role of proteins such as TLR4 in their function is challenging. Here, we show that primary ...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2008.02949.x
更新日期:2009-06-01 00:00:00
abstract::Undesired immunological responses to products of therapeutic gene replacement have been obstacles to successful gene therapy. Understanding such responses of the host immune system to achieve immunological tolerance to a transferred gene product is therefore crucial. In this article, we review relevant studies of immu...
journal_title:Immunology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2567.2009.03069.x
更新日期:2009-05-01 00:00:00
abstract::We performed a genomic study combining single-cell mRNA differential display and RNA subtractive hybridization to elucidate CD8 T-cell quiescence/ignorance. By comparing actively maintained quiescent CD8 T cells from liver tumour tumour-infiltrating lymphocytes (TILs) with quiescent T cells at the single-cell level, w...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2008.02926.x
更新日期:2009-05-01 00:00:00
abstract::In the past 15 years, regulatory T cell (Treg) suppression has graduated from a phenomenon that 'dare not speak its name' to a field at the centre of a global research effort. It is now accepted that Tregs can target numerous cell populations to elicit potent immunosuppression. Intriguingly, emerging data suggest that...
journal_title:Immunology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2567.2009.03053.x
更新日期:2009-04-01 00:00:00
abstract::It has been suggested that tumour cell lysis by gamma-radiation induces a tumoral antigen release eliciting an immune response. It is not clear how a specific immune response in cervical cancer patients is developed after radiotherapy. This study is an attempt to investigate the role of the human papillomavirus type 1...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2008.02912.x
更新日期:2009-04-01 00:00:00
abstract::We and others have established an important role for phosphoinositide-3 kinase gamma (PI3Kgamma) in the chemotactic responses of macrophages and neutrophils. The involvement of this lipid kinase in allergic inflammatory responses is, however, yet to be fully determined. Here we compare wild-type (WT) and PI3Kgamma(-/-...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2008.02908.x
更新日期:2009-03-01 00:00:00
abstract::DNA breaks play an essential role in germinal centre B cells as intermediates to immunoglobulin class switching, a recombination process initiated by activation-induced cytidine deaminase (AID). Immunoglobulin gene hypermutation is likewise catalysed by AID but is believed to occur via single-strand DNA breaks. When i...
journal_title:Immunology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2567.2008.03050.x
更新日期:2009-03-01 00:00:00
abstract::Oral tolerance promotes a generalized decrease in specific immune responsiveness to proteins previously encountered via the oral route. In addition, parenteral immunization with a tolerated protein also triggers a significant reduction in the primary responsiveness to a second unrelated antigen. This is generally expl...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2008.02901.x
更新日期:2009-03-01 00:00:00
abstract::Previously, a putative immunosuppressant-coding gene was identified from a complementary DNA library derived from the salivary glands of partially-fed Haemaphysalis longicornis. Using real-time polymerase chain reaction, the gene was shown to be predominantly expressed during blood feeding with the site of expression ...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2008.02890.x
更新日期:2009-02-01 00:00:00
abstract::Interleukin-15 (IL-15) is a proinflammatory cytokine that is overexpressed in rheumatoid arthritis (RA), a disease characterized by activation of monocytes/macrophages (MPhi), and by expansion of autoreactive CD4(+) T cells. We hypothesized that IL-15 plays a major role for this expansion of CD4(+) T cells and modulat...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2008.02878.x
更新日期:2009-01-01 00:00:00
abstract::Activated T cells, through the production of the receptor activator of NF-kappaB ligand (RANKL) cytokine, have been implicated in the osteoclast development and bone loss that are associated with autoimmune diseases such as rheumatoid arthritis. However, the cellular pathways that regulate the expression of RANKL and ...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2008.02858.x
更新日期:2008-11-01 00:00:00
abstract::Crohn's disease (CD) is a chronic inflammatory disease of the gastrointestinal tract. Its pathogenesis is not completely understood, though the prevailing model is that the intestinal flora drives a strong intestinal T helper 1 (Th1)/Th17 type immune response and inflammation in the genetically susceptible host. This ...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2008.02839.x
更新日期:2008-10-01 00:00:00
abstract::The endogenous cannabinoid system plays an important role in regulating the immune system. Modulation of endogenous cannabinoids represents an attractive alternative for the treatment of inflammatory disorders. This study investigated the effects of URB597, a selective inhibitor of fatty acid amide hydrolase (FAAH), t...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2008.02838.x
更新日期:2008-10-01 00:00:00
abstract::In the present study, we have analysed the phenotype of EphB2 and/or EphB3 deficient thymocytes confirming and extending previous studies on the role of this family of molecules in T-cell differentiation. In all mutant thymuses statistically significant reduced cell contents were observed. This reduction of thymic cel...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2008.02828.x
更新日期:2008-09-01 00:00:00
abstract::Growth of Salmonella enterica in mammalian tissues results from continuous spread of bacteria to new host cells. Our previous work indicated that infective S. enterica are liberated from host cells via stochastic necrotic burst independently of intracellular bacterial numbers. Here we report that liver phagocytes can ...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2008.02814.x
更新日期:2008-09-01 00:00:00
abstract::A critical role for leukotriene B(4) (LTB(4)) and/or platelet-activating factor (PAF) in regulating polymorphonuclear cell (PMN) trafficking to inflammatory sites has been reported in a number of experimental inflammatory models. In vitro, newly synthesized LTB(4) and PAF were shown to act in an autocrine/paracrine or...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2007.02767.x
更新日期:2008-07-01 00:00:00
abstract::We previously identified a cis-acting element within the 3' untranslated region of CD40 ligand messenger RNA (mRNA) that is composed of three complex binding sites and acts to increase mRNA stability in both in vitro and in vivo systems. We now demonstrate the functional consequences of the three binding sites with re...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2007.02783.x
更新日期:2008-07-01 00:00:00
abstract::Epididymitis represents a serious threat to male fertility and usually develops following secondary bacterial infection of the epididymis such as urinary tract infections or sexually transmitted diseases. Surprisingly, very little is known about the innate host response triggered by bacterial infection in the male rep...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2007.02763.x
更新日期:2008-06-01 00:00:00
abstract::Identifying the properties of a molecule involved in the efficient activation of the innate and adaptive immune responses that lead to long-lasting immunity is crucial for vaccine and adjuvant development. Here we show that the papaya mosaic virus (PapMV) is recognized by the immune system as a pathogen-associated mol...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2007.02753.x
更新日期:2008-06-01 00:00:00
abstract::Peroxisome proliferator activated receptor-gamma (PPARgamma) has been reported to exert anti-inflammatory properties in endotoxic shock and sepsis. One phenomenon that alters the inflammatory response to endotoxin [lipopolysaccharide (LPS)] is endotoxin tolerance, which is caused by previous exposure to endotoxin. Her...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2007.02734.x
更新日期:2008-05-01 00:00:00
abstract::Vaccination strategies that can block or limit heterosexual human immunodeficiency virus (HIV) transmissions to local and systemic tissues are the goal of much research effort. Herein, in a mouse model, we aimed to determine whether the enhancement of antibody responses through mucosal and systemic immunizations, prev...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2007.02702.x
更新日期:2008-03-01 00:00:00
abstract::Glucosamine (GlcN) has been reported to possess several biomedical properties, and currently a great deal of attention has been focused on improving the functional properties of GlcN for different applications. Therefore, this study was conducted to introduce a carboxybutyryl functional group to GlcN and to find out t...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2007.02683.x
更新日期:2008-03-01 00:00:00
abstract::Humans and other mammals coexist with a diverse array of microbes colonizing the intestine, termed the microflora. The relationship is symbiotic, with the microbes benefiting from a stable environment and nutrient supply, and the host gaining competitive exclusion of pathogens and continuously maintenance of the gut i...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2007.02687.x
更新日期:2008-02-01 00:00:00
abstract::Therapeutic vaccination using T-cell receptor (TCR) peptides from V genes commonly expressed by potentially pathogenic T cells remains an approach of interest for treatment of multiple sclerosis (MS) and other autoimmune diseases. We developed a trivalent TCR vaccine containing complementarity determining region (CDR)...
journal_title:Immunology
pub_type: 临床试验,杂志文章
doi:10.1111/j.1365-2567.2007.02703.x
更新日期:2008-01-01 00:00:00
abstract::Autoimmune diabetes is predominated by a T helper 1 (Th1) response at the expense of an impaired Th2 response. Although T cells producing Th2 cytokines are generally thought to counter a Th1 response, there have been reports of Th2 T-cell clones with pathogenic activity, including one previously reported by us in whic...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2007.02715.x
更新日期:2008-01-01 00:00:00
abstract::I have briefly reviewed the factors that motivated me to change my views about the existence and importance of suppressor/regulatory T cells and to devote the majority of my laboratory efforts to this newly revitalized area of immunologic research. I am optimistic that manipulation of regulatory T-cell function will s...
journal_title:Immunology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2567.2007.02777.x
更新日期:2008-01-01 00:00:00
abstract::GD3, a ganglioside expressed on melanoma, is the only tumour-associated glycolipid described to date that can induce a CD1d-restricted natural killer T (NKT)-cell response. We analysed the fine specificity of GD3-reactive NKT cells and discovered that immunization with GD3 induced two populations of GD3-reactive NKT c...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2007.02760.x
更新日期:2008-01-01 00:00:00
abstract::Circulating CD4+ CD25+ regulatory T cells (Tregs) have been demonstrated to maintain immunotolerance and suppress the antigen-specific or antigen-non-specific T-cell responses, but their role in chronic hepatitis B (CHB) infection in humans has not been well characterized. In this study, we analysed the frequency and ...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2007.02691.x
更新日期:2008-01-01 00:00:00
abstract::Interleukin-31 (IL-31) is a novel T-helper-lymphocyte-derived cytokine that plays an important role in allergic skin inflammation and atopic dermatitis. It has recently been implicated in bronchial inflammation. We investigated the functions and mechanisms of IL-31-induced activation of human bronchial epithelial cell...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2007.02668.x
更新日期:2007-12-01 00:00:00
abstract::Osteopontin (OPN) is important for the function of fibroblasts, macrophages and lymphocytes during inflammation and wound healing. In recent studies of experimental colitis we demonstrated exacerbated tissue destruction in OPN-null mice, associated with reduced tumour necrosis factor-alpha expression and increased mye...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2007.02682.x
更新日期:2007-12-01 00:00:00
abstract::Post-translational modifications of histone proteins are major mechanisms that modify chromatin structure and regulate gene expression in eukaryotes. Activation of histone acetyltransferases or inhibition of histone deacetylases (HDACs) is generally believed to allow chromatin to assume a more open state, permitting t...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2007.02678.x
更新日期:2007-12-01 00:00:00
abstract::Dendritic cells (DC) are powerful inducers of primary T-cell responses, but their role in secondary responses has not been extensively analysed. Here, we address the role of two DC subsets derived from human CD16(+) (16(+) mDC) or CD16(-) (16(-) mDC) monocytes on the reactivation of memory responses. CD4(+) CD45RA(-) ...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2007.02650.x
更新日期:2007-11-01 00:00:00
abstract::Defective regulation of secondary immunoglobulin V(D)J gene rearrangement promotes the production of autoantibodies in systemic lupus erythematosus (SLE). It remains unclear, however, whether the regulation of the recombination-activating genes RAG1 and RAG2 is effective in SLE. RAG1 and RAG2 messenger RNA expression ...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2007.02649.x
更新日期:2007-11-01 00:00:00
abstract::Chemokine-mediated signalling involves the activation of a Janus kinase (Jak) pathway. We have previously shown that Jak3 mediates CCR9 and CXCR4 signalling in response to CCL25 and CXCL12 in BM progenitors and thymocytes. The lack of peripheral lymph nodes and Peyer's patches observed in Jak3(-/-) mice suggested a po...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2007.02634.x
更新日期:2007-10-01 00:00:00
abstract::Nasal carriage of Staphylococcus aureus is an important source of nosocomial infection and community-acquired methicillin-resistant S. aureus (MRSA). Previous studies by our laboratory revealed that nasal carriage of S. aureus is accompanied by subclinical inflammation, which is insufficient to prevent colonization, a...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2007.02615.x
更新日期:2007-09-01 00:00:00
abstract::Microbial adjuvants are essential for the development of T-cell-dependent antibody production, recall T-cell proliferation and interferon-gamma production following immunization with protein antigens. Using an adoptive transfer approach, we showed that the adjuvant lipopolysaccharide enhanced the frequency of cells pr...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2007.02620.x
更新日期:2007-09-01 00:00:00
abstract::Although it is clear that the CD45 tyrosine phosphatase is required for efficient T-cell activation and T-cell development, the factors that regulate CD45 function remain uncertain. Previous data have indicated that there is an association of CD45 with CD4 and the T-cell receptor (TCR) complex controlled by the variab...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2007.02602.x
更新日期:2007-08-01 00:00:00
abstract::Histamine not only mediates immediate allergic reactions, it also regulates cellular immune responses. H4R is the most recently identified histamine receptor (HR). In the present study, we examined the in vitro effect of histamine and H4R agonists on the responses of human T cells to purified protein derivative from M...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2007.02574.x
更新日期:2007-06-01 00:00:00
abstract::Cancer immune surveillance is considered to be an important host protection process to inhibit carcinogenesis and to maintain cellular homeostasis. In the interaction of host and tumour cells, three essential phases have been proposed: elimination, equilibrium and escape, which are designated the 'three E's'. Several ...
journal_title:Immunology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2567.2007.02587.x
更新日期:2007-05-01 00:00:00